RNA ADP-ribosylation

A few years ago, work was published which showed that under certain conditions, some PARPs can modify RNA with ADP-ribose in vitro. Many questions were left unanswered: can all PARPs do this? Do they modify RNA in cells? What is the function of RNA ADP-ribosylation, how does it influence the modified molecules? We were intrigued...

Available PhD position

We are looking for a PhD candidate to strengthen our team starting Autumn 2022! More details about the project are available below, or you can also get in touch with informal inquiries. phd-position-summer-2022Download

How to visualise ADP-ribosylation

We are studying the modification of proteins with ADP-ribose. Quite recently, reagents have been developed to visualise this. While doing some experiments, we quickly realised that not all detection reagents are equally well suited for all methods and substrates. Therefore we decided to cross-validate the available reagents and tested them on a range of substrates;...

Student positions to study ADP-ribosylation in cancer and viral infection

We are recruiting one or two master/medical PhD students! Below are global outlines of possible research projects, which can be further developed according to students interests. One project has a more translational aspect and is well suited for a medical PhD student. PARP1 is utilised as drug target in for example BRCA1 negative breast cancer...

Two PhD positions available

We currently have two open PhD student positions, funded by the DFG for three years. You can find the essentials on jobRxiv or a more detailed PDF as download available below. 202110-student-job-advertDownload

How not to apply for a position in our lab

We are getting an increasing amount of requests for students' placements. Unfortunately, many of those emails are very generic and for example do not mention when they want to join us, nor why they want to work in our lab, nor what their backgrounds and skills are. This kind of emails tends to get one...

Changes in student staff

Petra, who joined us in September, has finished her bachelor internship. Thanks to COVID19 and social distancing, we could not have a leaving get-together as we'd like, but Petra brought cake anyway. And left this little note: Her project did not go at all as expected (or hoped) - turns out our hypothesis was wrong!...

Towards more reproducible science?

When reading scientific literature, one of my pet peeves is definitely the methods section. "Plasmid X was described here" - but it wasn't. "Protein purification was detailed in earlier work" - but you have to go through 10 sequentially cited papers to find the original source. If you're lucky, you may find what you're looking...

Why and how we wrote a review during lockdown

At the end of 2019, Lisa Weixler was the first PhD student to join our lab. In Spring 2020 Jeffrey Momoh and Katja Schäringer joined. Jeff joined us for his master thesis, Katja joined our Department as PhD student and is co-supervised by us. As the lockdown hit in March, we were left wondering what...

New Year’s Resolutions

Even in the middle of the still-raging SARS-CoV-2 pandemic, we think that climate is a topic we shouldn't forget. Therefore our New Year's Resolution: also in the lab less plastic, more re-use... Glass bottles instead of falcons for solutions; re-using plastics where possible. We always welcome suggestions to make our lab more sustainable!